<p>Inhibition of Glioma Cells’ Proliferation by Doxorubicin-Loaded Exosomes via Microfluidics</p>
نویسندگان
چکیده
منابع مشابه
Phenotypic modulation of auto-reactive cells by insertion of tolerogenic molecules via MSC-derived exosomes
Auto-reactive cells-mediated immune responses are responsible for the current tissue damages during autoimmunity. Accordingly, functional modulation of auto-reactive cells has been a pivotal aim in many of recent studies. In the current study, we investigated the possibility for insertion of regulatory molecules onto auto-reactive cells through exosomal nano-shuttles as a novel approach for phe...
متن کاملDoxorubicin and Doxorubicin-loaded Nanoliposome Triggers Hepatocyte Cells Senescence through Accumulation of Inflammatory Factors and Activation of P53
Background and purpose: Induction of cellular senescence is indicative of new strategy to prevent abnormal proliferation of cancer cells. Doxorubicin (DOX) is gaining attention for its neoplasia suppressive and inhibitory properties, but its clinical utility is limited due to irreversible effects on non-target cells/tissues. In this way, nanoliposomal structures were developed in drug delivery ...
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auto-reactive cells-mediated immune responses are responsible for the current tissue damages during autoimmunity. accordingly, functional modulation of auto-reactive cells has been a pivotal aim in many of recent studies. in the current study, we investigated the possibility for insertion of regulatory molecules onto auto-reactive cells through exosomal nano-shuttles as a novel approach for phe...
متن کاملDendritic cells loaded with tumor derived exosomes for cancer immunotherapy
Exosomes are vesicles that can be secreted by many types of cell and released into the extracellular space. Studies have found that tumor derived exosomes (TEXs) can promote tumor growth and metastasis, as well as inhibit immune response through transferring their genetic information to the recipient cells. Given their functions in tumor progression, TEXs are considered as promising biomarkers ...
متن کاملDying endothelial cells stimulate proliferation of malignant glioma cells via a caspase 3-mediated pathway
Emerging evidence has indicated that apoptotic cells have a compensatory effect on the proliferation of neighboring cells. However, the potential role of dying vascular endothelial cells (ECs) in glioma tumor proliferation remains unclear. In the present study, three glioma cell lines were cocultured with dying ECs under various conditions to evaluate the effect of dying ECs on tumor proliferat...
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ژورنال
عنوان ژورنال: International Journal of Nanomedicine
سال: 2020
ISSN: 1178-2013
DOI: 10.2147/ijn.s263956